3 edition of The therapeutic role of androgens found in the catalog.
The therapeutic role of androgens
|Statement||S. Bhasin, guest editor.|
|Series||Baillière"s clinical endocrinology and metabolism : international practice and research -- 12/3, Baillière"s clinical endocrinology and metabolism -- 12/3.|
|Contributions||Bhasin, Shalender, 1953-|
|The Physical Object|
|Number of Pages||542|
Often overlooked is the role that hormones play as key regulators of human muscle metabolism and their influence on physical function. Aging is associated with a loss of sex hormones (androgens and estrogens), which in turn may be responsible for triggering muscle loss, muscle weakness, decreased functional performance, and decreased life span. Androgen Deprivation Therapy: An Essential Guide for Prostate Cancer Patients and Their Loved Ones (Large Print 16pt) By John W Robinson. Studying the Role of Androgen Receptor Signaling in the Development, Progression and Therapeutic Approach of Prostate Cancer.
(). Possible role of androgen receptor gene in therapeutic response of infertile men with hypogonadotropic hypogonadism. Systems Biology in Reproductive Medicine: Vol. 65, No. 4, . Androgens, such as testosterone, have important hormonal influences on the brain and may prevent and possibly treat cognitive loss, including age-associated memory loss, mild cognitive impairment (MCI), and perhaps even Alzheimer’s disease (AD).There is support from small, prospective clinical trials that suggest the role of testosterone in.
groups, and were tasked with addressing the role of ADT in specific PC settings: 1. Primary ADT in newly diagnosed disease. 2. Neoadjuvant ADT before radical prostatectomy (RP) or radiation therapy (RT). 3. ADT as salvage therapy. 4. ADT for BCR postdefinitive therapy. 5. ADT for castrate‐sensitive prostate cancer (CSPC) and castrate‐. Androgens, the predominant male sex hormones, drive the development and maintenance of male characteristics by binding to androgen receptor (AR). As androgens are systemically distributed throughout the whole organism, they affect many tissues and cell types in addition to those in male sexual organs. It is now clear that the immune system is a target of androgen .
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Major conclusions. Androgen excess plays a prominent role in the development of metabolic disturbances associated with PCOS, with a discernible impact on key peripheral metabolic tissues, including the adipose, liver, pancreas, and muscle, and very prominently the brain, contributing to the constellation of metabolic complications of PCOS, from obesity to insulin by: 5.
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Androgens are important in male physiology because of their essential roles in male sexual differentiation, male puberty changes, maintenance of muscle and bone mass, prostate growth, and spermatogenesis in adults. The androgen receptor (AR) is a member of the steroid and nuclear receptor superfamily, and an important drug by: 8 Therapeutic role of androgens in the treatment of osteoporosis in men LAURENCE KATZNELSON MD Assistant Professor of Medicine, Harvard Medical School Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA There has been much recent interest in the relationship between androgens and bone mineralization in by: Metabolic Dysfunction in Polycystic Ovary Syndrome: Pathogenic Role of Androgen Excess and Potential Therapeutic Strategies Article (PDF Available) in Molecular Metabolism 35.
Pharmacologic androgen therapy uses androgens to maximal therapeutic efficacy within adequate safety limits but without regard to androgen type, dose, duration of treatment or gender. In this, the goal is to improve mortality and/or morbidity of an underlying non-gonadal disease through eliciting androgen effects on muscle, bone, brain, or.
Objectives:We reviewed the mechanism of androgen actions and the established and experimental uses of antiandrogens in women. Methods:Relevant studies were identified through a computerized bibliographic search (MEDLINE) and through manual review of bibliographies in relevant publications.
Results:Androgens exert major effects on the functions of gonals, sex organs, and various. Androgen‐deprivation therapy (ADT) is commonly used for treatment of advanced prostate cancer. Depression plays an important role in suicidal behaviour, while ADT in the treatment of prostate cancer is associated with an increased risk of depression.
Role Of Androgens In Causing Hair Loss. Despite there being a cascade of events that lead to hair loss, the presence of too many androgens is ultimately what causes follicular miniaturization. However, the effects of exogenous androgens on the human body will inevitably vary between individuals due to several dependant factors in this cascade.
Androgens also play an important role in bone physiology. Postmenopausal women with hip fracture were found to have significantly lower free testosterone level. The mechanism by which estrogens can promote the growth of breast cancer has been clearly shown.
However, the role of androgens is less clear. Authoritative and wide-ranging, Androgens in Health and Disease offers both researchers and practicing clinicians a comprehensive survey of how, why, and where androgens exert their effects, as well as their therapeutic roles in a broad range of diseases.
Anti-androgens are medications with many uses, from treating prostate cancer to reducing masculine features. Learn more about these powerful drugs and some of the most common ones.
Sex hormones and their respective receptors affect vascular function differently in men and women, so it is reasonable to assume they play a role in the sex differences in cardiovascular disease states.
This review focuses on how the effects of testosterone on arterial vessels impact the female vasculature. In women with androgen-excess polycystic ovary syndrome, and in transgender men.
• The role of androgens in maintaining well-being in women is not fully understood. Between a woman’s mids and early 60s, adrenal androgen production reduces by about two-thirds.
After a natural menopause, ovarian production continues to a variable degree. After bilateral oophorectomy, ovarian production of androgens and.
Androgen, any of a group of hormones that primarily influence the growth and development of the male reproductive system. The predominant and most active androgen is testosterone, which is produced by the male testes.
The other androgens, which support the functions of testosterone, are produced. Electronic books: Additional Physical Format: Print version: Androgens in health and disease. # Androgens--therapeutic use\/span>\n \u00A0\u00A0\u00A0\n schema and practicing clinicians a comprehensive survey of how, why, and where androgens exert their effects, as well as their therapeutic roles in a broad range of diseases.\/span.
Title:The Epidemiological, Mechanistic and Potential Clinical Role of Androgen Receptor (AR) in Urothelial Carcinoma VOLUME: 17 ISSUE: 2 Author(s):Maria T. Bourlon and Thomas W. Flaig Affiliation:University of Colorado, School of Medicine, Division of Medical Oncology, University of Colorado Cancer Center, MSE.
17th Avenue, RoomAurora, COUSA. Androgens - Use Sexual therapeutic uses. Testosterone (Delatestril*,Androgel*, Testim*) and dihydrotestosterone are used for the treatment of the androgenic deficiencies: peripubertal hypogonadisms of testicular or pituitary origin, hypogonadism of the adult and oligospermia.
In this last case, they are used either with moderated doses, or in. Hormone therapy is also called androgen suppression therapy. The goal is to reduce levels of male hormones, called androgens, in the body, to stop them from fueling prostate cancer cells.
Androgens stimulate prostate cancer cells to grow. The main androgens in the body are testosterone and dihydrotestosterone (DHT). Additional research is needed into the role of local androgen production, action, and metabolism in tissues.
Both animal and human model systems may be used to determine the effects of a lack of androgens to define the clinical syndrome of androgen deficiency and to study the benefits and risks of androgen therapy. As a topical therapy for androgenetic alopecia, rosemary leaf extract was found in a study to improve hair regrowth in mice with androgen-induced hair-growth interruption.
40 The extract showed inhibitor activity upwards of % in inhibiting 5α-reductase, and also decreased the binding of DHT to androgen receptors. Gonadal steroids play a crucial role in maintaining the anatomical and functional integrity of all the structures involved in feminine sexual response.
While the role of estrogens on the activity of neuroendocrine circuitries and on the trophism of genital organs has been well established, the contr .Emerging evidence has suggested that androgen receptor signaling plays an important role in ovarian cancer outgrowth.
Specifically, androgen receptor activation appears to be associated with increased risks of developing ovarian cancer and inducing tumor progression. However, conflicting findings have also been reported. This review summarizes and discusses the available data indicating the.